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T9073 |
SRS16-86
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|
Ferroptosis
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SRS16-86 is a novel third-generation ferrostatin, is an inhibitor of ferroptosis. |
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T14960 |
Chroman 1
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ROCK
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Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM). |
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T4612 |
NS309
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|
EGFR
,
Potassium Channel
,
HER
|
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NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... |
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T36851L |
Peptide5 acetate
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Others
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Peptide5 acetate reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 acetate significantly reduces the degree of spinal cord injury (SCI) in a rodent ex vivo model. |
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T78575 |
KCL-286
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|
Retinoid Receptor
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KCL-286 is an orally available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI). |
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T71356 |
Lanperisone HCl
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|
|
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Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK43... |
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T60086 |
TTBK1-IN-2
|
N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
Microtubule Associated
|
|
TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures ... |
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T23215L |
(R)-3,4-DCPG HCl
|
(R)-3,4-DCPG HCl(201730-10-1 Free base) |
GluR
|
|
(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. |
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T27397 |
Gacyclidine
|
GK 11,OTO311,OTO-311,OTO 311,GK-11 |
NMDAR
|
|
Gacyclidine (OTO311) is a small molecule N-methyl-D-aspartate (NMDA) receptor antagonist. Local injection of Gacyclidine in the cochlea inhibits salicylate-induced tinnitus and can be used to treat brain injury, spinal c... |
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T1065 |
Baclofen
|
Lioresal |
GABA Receptor
|
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Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp... |
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T8630 |
Baclofen hydrochloride
|
4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride |
GABA Receptor
|
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Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe... |
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T28978 |
Tirilazad mesylate
|
U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate |
Antiviral
|
|
Tirilazad mesylate (U 74006F) is a non-glucocorticoid, lipid peroxidation inhibitor with antiviral activity and neuroprotective activity.Tirilazad mesylate confines intracellular intramembranous foci, attenuates spinal c... |
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T67929 |
Linoleoyl glycine
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|
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Linoleoyl glycine, a modified polyunsaturated fatty acid, is an endogenous homologue of linoleoyl glycine. Linoleoyl glycine activates human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in xenopus oocytes from mammalia... |
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T14198 |
ALX-1393
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GlyT
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ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu... |
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T3354 |
BIA 10-2474
|
BIA10-2474 |
FAAH
,
Autophagy
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|
BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest o... |
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T28778 |
Silperisone HCl
|
RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336 |
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Silperisone HCl (RGH-5002) blocks sodium and calcium channels in cells, decreases excitability and contractility of muscle cells, reduces peripheral tone, and acts as a muscle relaxant and peripheral vasodilator. Silperi... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T33324 |
Methionyl-tyrosyl-lysine
|
Met-tyr-lys |
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Methionyl-tyrosyl-lysine is a tripeptide from the spinal cord. |
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T25009 |
AK 275
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AK275,AK-275 |
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AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro. |
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T32658 |
Leteprinim potassium
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SPI-205,AIT-082,SPI 205,AIT082,AIT 082,SPI205 |
|
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Leplinine (AIT-082, SPI-205) is a neurotrophic agent that may be used to treat Alzheimer's disease and spinal cord injury. |
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T14187 |
ALLM
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Calpain inhibitor II |
Others
|
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ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2]. |
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T21338 |
Methylprednisolone Acetate
|
Depo-Medrate,Depometicort,Depo-Medrin,Depo-medrol,Depomedrone,Lemod |
Reactive Oxygen Species
|
|
Methylprednisolone Acetate(Depo-Medrate) has the ability to inhibit oxygen free radicals and can be used to treat acute spinal cord injuries. |
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T28129 |
Naltalimide
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TRK-130,TRK 130,TRK130 |
|
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Naltalimide is a unique µ-opioid receptor partial agonist. Naltalimide also enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord. |
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T32180 |
Iophendylate
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Maiodil,Panthopaque,Iodophendylate,Ethiodan,Ioglunide |
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Iofendylate is a molecule used as a contrast medium. It is an absorbable iodized fatty acid of low viscosity used for roentgenography of the spinal cord, biliary tree, sinuses, and body cavities. |
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T25110 |
AS1069562
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AS-1069562,AS 1069562 |
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AS1069562 is an inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake which acts by notably restoring reduced insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and s... |
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T31105 |
CS 722
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CS-722,CS722 |
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CS 722 is a centrally acting muscle relaxant. CS-722 exerts its muscle relaxant action by affecting both the supraspinal structure and the spinal cord. |
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T36851 |
Peptide5
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|
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Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll ... |
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T17306 |
(R)-Baclofen hydrochloride
|
Arbaclofen hydrochloride |
GABA Receptor
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Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal site... |
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T70647 |
CD2019
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CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. |
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T81492 |
Phenylbenzothiazole-PEG4-OH
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|
|
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Phenylbenzothiazole-PEG4-OH (compound 1) has therapeutic potential for spinal cord injury and may enhance spine formation [1]. |
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T82947 |
Atinumab
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ATI355,6A3-IgG4 |
|
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Atinumab (6A3-IgG4), an antibody, has potential applications in spinal cord injury (SCI) research [1]. |
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T75550 |
Hyp9
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|
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Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1]. |
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T28786 |
SJA6017
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SJA-6017,Calpain Inhibitor VI,Calpain-In-4,SJA 6017,Calpain Inhibitor 4 |
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SJA6017 is a inhibitor of calpain-1 (IC50 = 7.5 nM) and calpain-2 ( IC50 = 78 nM). SJA6017 also inhibits cathepsins B (IC50s = 15 nM) and cathepsins L (IC50s = 1.6 nM). SJA6017 reduces apoptotic cell death, preserves spi... |
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T40602 |
Z-LEHD-FMK TFA
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|
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Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective pot... |
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T60514 |
Triprolidine
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|
|
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Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3]. |
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T38281 |
C22 Galactosylceramide (d18:1/22:0)
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|
|
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C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricte... |
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T37476 |
Cyclo(L-Phe-L-Val)
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|
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Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It indu... |
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T80900 |
Unasnemab
|
MT-3921,rH116A3 |
|
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Unasnemab (MT-3921), a humanized IgG1 monoclonal antibody, targets repulsive guidance molecule A (RGMa) to enhance locomotor function and support neuroregeneration, showing potential for spinal cord injury research [1]. |
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TP1662 |
Galanin Receptor Ligand M35
|
|
|
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The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic isl... |
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T69429 |
Y27632 HCl hydrate
|
|
|
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Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepa... |
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T36925 |
Neuromedin C (porcine)
|
|
|
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Neuromedin C (porcine) is a bombesin-like neuropeptide obtained from the porcine spinal cord. Neuromedin C (porcine) has contractile activity in the rat uterus. Neuromedin C (porcine) has the potential to study neurologi... |
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T62511 |
AZ3391
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|
|
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AZ3391 is a quinoxaline derivative that is a potent inhibitor of PARP. AZ3391 has potential for the study of diseases and conditions occurring in central nervous system tissues (e.g., brain and spinal cord). |
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T78061 |
Peptide5 TFA
|
|
Gap Junction Protein
|
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Peptide5 TFA, a connexin 43 mimetic peptide, mitigates swelling, astrogliosis, and neuronal cell death in animal models of spinal cord injury. Additionally, it suppresses the NLRP3 inflammasome, functioning as an anti-in... |
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T82798 |
C3bot(154-182) TFA
|
|
|
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C3bot(154-182) TFA, a C3 peptide, facilitates spinal cord injury recovery by promoting regenerative growth of descending fiber tracts. It serves as a potential therapeutic agent to support axonal protection and/or repair... |
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T33789 |
Oleoyl proline
|
N-Oleoyl-l-proline |
|
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Oleoyl proline is an N-acyl amine that can be detected in bovine brain extracts and D. melanogaster larvae using mass spectrometry. In a preclinical model of pain, mice lacking fatty acid amide hydrolase (FAAH KO) had de... |
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T80544 |
PTPσ Inhibitor, ISP
|
|
Phosphatase
|
|
PTPσ Inhibitor ISP is a compound that binds to recombinant human PTPs, thereby inhibiting PTPσ signaling. It has the capability to penetrate membranes and counteract the inhibitory effects of chondroitin sulfate proteogl... |
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T35496 |
(±)13(14)-EpDPA
|
|
|
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bo... |
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T71243 |
ASP3662
|
|
|
|
ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neu... |
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T35493 |
(±)10(11)-EpDPA
|
|
|
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Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bo... |
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T38282 |
C22 Glucosylceramide (d18:1/22:0)
|
|
|
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C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precurs... |
